5 Simple Techniques For prometheus gen 2 powder measure
5 Simple Techniques For prometheus gen 2 powder measure
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Due to risks of habit, abuse, and misuse with opioids, even at encouraged doses, reserve Promethazine HCl and Codeine Phosphate Oral Answer for use in Grownup people for whom some great benefits of cough suppression are predicted to outweigh the dangers, and in whom an adequate assessment on the etiology in the cough has been built.
Excessively significant dosages of antihistamines, like promethazine hydrochloride, in pediatric people may possibly induce unexpected Demise (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric clients. In pediatric people who are acutely unwell affiliated with dehydration, There's an elevated susceptibility to dystonias with using promethazine HCl.
Pregnancy Assessments Diagnostic pregnancy checks according to immunological reactions concerning HCG and anti-HCG might end in false-negative or Untrue-positive interpretations.
Impaired secretion from sweat glands next toxic doses of medicine with anticholinergic Uncomfortable side effects might predispose to hyperthermia.
Avoidance and Charge of nausea and vomiting associated with specified varieties of anesthesia and surgical procedure.
Focus–Adverse Response Relationships There is a romance in between growing codeine plasma concentration and increasing frequency of dose- linked opioid adverse reactions such as nausea, vomiting, CNS results, and respiratory melancholy.
Promethazine hydrochloride and codeine phosphate must be presented into a Expecting woman only if clearly wanted.
Children Postmarketing situations of respiratory despair, which includes fatalities, are actually claimed with usage of promethazine in pediatric patients. Concomitant administration with other respiratory depressants may possibly improve the hazard of respiratory melancholy.
Promethazine HCl Oral Solution may well decreased seizure threshold. It ought to be employed with warning in folks with seizure Conditions or in individuals who will be making use of concomitant medicines, including narcotics or neighborhood anesthetics, which may also have an effect on seizure threshold.
Prevention and control of nausea and vomiting connected with specific forms of anesthesia and surgery.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients lower than six several years of age, due to the fact The mix may perhaps result in fatal respiratory depression Within this age population. It is vital that promethazine hydrochloride and codeine phosphate syrup is measured using an exact measuring system (see PRECAUTIONS-Information and facts for Individuals).
The opioid antagonists, naloxone and nalmefene, are particular antidotes for respiratory depression resulting from opioid overdose. For clinically important respiratory or circulatory melancholy secondary to codeine overdose, administer an opioid antagonist. An antagonist should not be administered within the absence of clinically significant respiratory melancholy. Since the length of opioid reversal is predicted to be less than the period of motion of codeine in Promethazine HCl and Codeine Phosphate Oral Resolution, meticulously watch the affected individual until eventually spontaneous respiration is reliably reestablished.
Lactation Not less than just one death was documented in a very nursing quagen pharma green toddler who was exposed to large amounts of morphine in breast milk because the mom was an ultra-rapid metabolizer of codeine.
Prevent the usage of Promethazine HCl and Codeine Phosphate Oral Solution in adolescents 12 to eighteen years of age who have other possibility things that may boost their sensitivity into the respiratory depressant effects of codeine. Chance factors contain ailments connected with hypoventilation, for instance postoperative position, obstructive slumber apnea, being overweight, serious pulmonary ailment, neuromuscular sickness, and concomitant usage of other medications that result in respiratory melancholy.